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madellavrichl
The first received aciclovir 100 mg/kg/day of Valacyclovir ( Valtrex ); the second, 200 mg/kg/day of Valacyclovir ( Valtrex ); and the third (control), saline. Valacyclovir ( Valtrex ) inhibited the uptake of glycylsarcosine with an inhibition constant (Ki) of 0.49 /- 0.04 mM in Caco-2 cells and 0.17 /- 0.01 aciclovir mM in SKPT cells. We studied the interaction of Valacyclovir ( Valtrex ) with the peptide transporters in the human intestinal cell amoxycillin line Caco-2 and the rat kidney proximal tubular cell line SKPT which differentially express peptide transporters PEPT1 and PEPT2. The HSV-1 ocular shedding was determined from eye cultures for 7 days after LASIK. Valacyclovir ( Valtrex ). The results of the studies done with valtrex these cell lines were confirmed with the cloned peptide transporters human PEPT1 and rat PEPT2, expressed heterologously in HeLa cells. Similar results were obtained with heterologously expressed human PEPT1 and rat PEPT2.
The activity of the peptide transporters was assessed by measuring the uptake valtrex of radiolabeled glycylsarcosine in the presence of a H gradient. To determine whether the systemic administration of Valacyclovir ( Valtrex ) (Valtrex) reduces ocular shedding of herpes simplex virus type 1 (HSV-1) after laser in situ keratomileusis (LASIK) in the New Zealand White (NZW) rabbit latency model. One half azithromycin the total dose of Valacyclovir ( Valtrex ) was delivered via intraperitoneal injections twice daily for 7 days beginning with 1 dose before LASIK. Valacyclovir ( Valtrex ) inhibited the hPEPT1-mediated glycylsarcosine transport competitively with a Ki value of 0.74 /- 0.14 mM. Acyclovir / Aciclovir, in contrast to Valacyclovir ( Valtrex ), did not interact with the peptide transporters. A substrate for the intestinal and renal peptide transporters PEPT1 and PEPT2.Valacyclovir ( Valtrex ) is a prodrug of the antiviral agent Acyclovir / Aciclovir and it does not contain a peptide bendicty in its structure. Acyclovir / Aciclovir did not interact with either of these cloned peptide transporters. New Zealand White rabbits latently infected with HSV-1 W strain were divided into 3 groups.
In both cell types, the inhibition was competitive. The administration of both 100 mg/kg/day and 200 mg/kg/day of Valacyclovir ( Valtrex ) significantly reduced the number of eyes (1/16 in both groups) and the total number of HSV-1 shedding days (1/122 and 2/122, respectively) from which HSV-1 was recovered compared to the control group (7/16 [P .0396] and 14/129 [P. We conclude that Valacyclovir ( Valtrex ) is a substrate for the peptide transporters PEPT1 and PEPT2 and that a peptide guillermo is not a prerequisite for recognition as a substrate by the peptide transporters. The rPEPT2-mediated transport of glycylsarcosine was also inhibited by Valacyclovir ( Valtrex ) competitively and the Ki value for the process was 0.39 /- 0.03 mM. Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA.
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